Current and Completed Analyses

Current Data Sharing Projects from API ADAD Colombia Baseline Data

TitleInstitutionDescriptionStatusFound At
Impact of methodological approaches to analysis of AB PET measuresBanner Alzheimer's InstituteComparing statistical approaches and their effect on interpretive AB PET
measures
In ProgressIn Progress
Trial Baseline Characteristics for API ADAD Colombia TrialGroupa de Neurosciences, Universidad de Antioquia & Banner Alzheimer's InstituteA description of the characteristics of this cohort including neurocognitive trends at baseline.In ProgressIn Progress
Age-related changes in clinical and cognitive measures measured in E2801-psen1 carriers and baseline AB PET measuresGroupa de Neurosciences, Universidad de Antioquia & Familial Dementia Neuroimaging Labratory, Massachusetts General HospitalAge-related changes in clinical and cognitive measures in E280A-psen1 mutation carriers and non-carriers as well as changes associated with years of education and assessmentment of clinical correlates of baseline AB PET measures.In ProgressIn Progress
Detailed analysis of API composite (APCC) by age and mutation status Alzheimer's Prevention Initiative, Banner Alzheimer's InstituteDetailed analysis of API composite (APCC) by age and mutation status in comparison with the API registry dataIn ProgressIn Progress
Effect of APOE4 carriage on biomarkersGroupa de Neurosciences, Universidad de AntioquiaTo detect and define the effect of APOE4 carriage on biomarkers as seen in the baseline cohort of the API ADAD Colombia trialIn ProgressIn Progress
Sex difference in cognition and imaging for the API ADAD Colombia trialGroupa de Neurosciences, Universidad de Antioquia & Banner Alzheimer's InstituteAnalysis of cognitive and imaging measures as defined by sexIn ProgressIn Progress
Common close design in the API ADAD Colombia trailDepartment of Neurosciences, University of San Diego School of Medicine & Banner Alzheimer's InstituteDiscussion and proposal of common close trial design in as a method of increasing statistical power for the API ADAD Colombia trialIn ProgressIn Progress
Structural equation modeling analysisBanner Sun Health Research InstituteStructural equation modeling analysis, explore multifactorial correlational structure among latent variables & demographics, mutation carrier status & manifest variablesIn ProgressIn Progress
Clinical, cognitive and non-cognitive characteristics of screening for API ADAD Colombia trialGroupa de Neurosciences, Universidad de AntioquiaDefining the characteristics of the screening cohort for API ADAD Colombia trialIn ProgressIn Progress
Biomarkers in preclinical Alzheimer's Disease based on the resting state fMRIGroupa de Neurosciences, Universidad de AntioquiaObserved characteristics of biomarkers in preclinical Alzheimer's DiseaseIn ProgressIn Progress
Comparison of API ADAD Colombia and Dominantly Inherited Alzheimer's Network cohortsBanner Alzheimer's InstituteEvaluation and comparison of the API and DIAN cohorts In ProgressIn Progress
White Matter Hyperintensitiy Volume and Florbetapir SUVR Load in PSEN1 E280 Carriers and Non-CarriersBanner Alzheimer's InstituteEvaluation of White Matter Hyperintensitiy Volume and Florbetapir SUVR Load in PSEN1 E280 Carriers and Non-CarriersIn ProgressIn Progress
Cholinergic basal forebrain volume and functional connectivity in asymptomatic PSEN1 E280A mutation carriers compared with non-mutation carriers from the Alzheimer’s Prevention Initiative Autosomal-Dominant Alzheimer’s Disease TrialDepartment of Psychosomatic Medicine, University of Rostock & German Center for Neurodegenerative Diseases (DZNE)1. Cholinergic BF volume and functional connectivity in the baseline data of asymptomatic PSEN1 E280A mutation carriers compared with non-mutation carriers from the Alzheimer’s Prevention Initiative Autosomal-Dominant Alzheimer’s Disease Trial.
2. Association of basal forebrain volume and posterior basal forebrain functional connectivity with amyloid load in asymptomatic PSEN1 E280A mutation carriers based on amyloid sensitive PET data.
In ProgressIn Progress
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